Recombinant Mouse EPO (C-6His)
Produktgrößen
10ug
£ POA
EPT129-10UG
Über dieses Produkt
- SKU:
- EPT129
- Zusätzliche Namen:
- Erythropoietin; Epoetin; EPO
- Weitere Details:
- Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis; where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted; glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys; whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities; including vascularization and proliferation of smooth muscle; neural protection during hypoxia; and stimulation of certain B cells. Genetic variation in erythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy; diabetic nephropathy leading to end-stage renal disease; and diabetic neuropathy.
- Molekulargewicht:
- 19.4 KDa
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Hersteller:
- ELK Biotechnology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.