Recombinant Human IL-25 (C-6His)
Produktgrößen
50ug
£ POA
EPT115-50UG
Über dieses Produkt
- SKU:
- EPT115
- Zusätzliche Namen:
- Interleukin-25; IL-25; Interleukin-17E; IL-17E; IL25; IL17E
- Weitere Details:
- Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins; which is comprised of six members (IL-17; IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus; but have considerable sequence divergence at the N-terminus. With the exception of IL-17B; which exists as a non-covalently linked dimer; all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Human interleukin-17E (IL17E); also referred to as Interleukin-25 (IL25); is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils; and present at very low levels in various peripheral tissues. IL25; together with IL17B; are ligands for the cytokine receptor IL17BR; and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8; as well as ERK; JNK; and p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic and immune functions; and additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells.
- Molekulargewicht:
- 17.8 KDa
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Hersteller:
- ELK Biotechnology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.