Recombinant Human THBS1 (C-10His)
Produktgrößen
10ug
£ POA
EPT088-10UG
Über dieses Produkt
- SKU:
- EPT088
- Zusätzliche Namen:
- Thrombospondin-1; THBS1; TSP; TSP1
- Weitere Details:
- Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain; an extended central region with one vWFC domain; 3 TSP type 1domains; 2 EGF-like domains; and 8 TSP type3 domains; and a globular TSP C-terminal domain. Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules. TSP-1 counteracts the angiogenic; hypotensive; and antithrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF; blocks VEGF R2 signaling on vascular endothelial cells(EC); and destabilizes adhesive contacts between EC. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP).
- Molekulargewicht:
- 129.2 KDa
- Reinheit:
- Greater than 85% as determined by reducing SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Hersteller:
- ELK Biotechnology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.