Recombinant Mouse CD5 (C-6His)
Produktgrößen
50ug
£ POA
EPT051-50UG
Über dieses Produkt
- SKU:
- EPT051
- Zusätzliche Namen:
- T-cell surface glycoprotein CD5; CD5; CD5 antigen; CD5 antigen (p56-62); CD5 molecule; LEU1T-cell surface glycoprotein CD5; Lymphocyte antigen T1;Leu-1; T1; Ly-1
- Weitere Details:
- CD5 is a transmembrane glycoprotein of the conserved scavenger receptor cysteine-rich (SRCR) superfamily and expressed on thymocytes; peripheral T cells and a subset of B cells (B1-a). Moreover; CD5 also was found expressed in small lymphocytic lymphoma; hairy cell leukaemia and mantle cell lymphoma cells. The long cytoplasmic tail of CD5 has no intrinsic enzymatic activity; but contains four tyrosine phosphorylation sites; including an immunoreceptor tyrosine-based (ITAM)-like motif (pseudo-ITAM) and an immunoreceptor tyrosine-based inhibitory (ITIM)-like motif (pseudo-ITIM); as well as multiple potential serine and threonine phosphorylation sites. It physically associates with the T cell antigen receptor (TCR) and B cell antigen receptor (BCR); where it negatively modulates the activation and differentiation signals transduced by these receptors. CD5 also plays an important role in protection from activation-induced cell death and in the recognition of pathogen associated molecular patterns (PAMPS) present on fungal surfaces.
- Molekulargewicht:
- 38.9 KDa
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Hersteller:
- ELK Biotechnology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.