QuicKey Pro Human DPP4 (Dipeptidyl Peptidase IV) ELISA Kit
Produktgrößen
24 tests
£134,00
E-OSEL-H0084-24TESTS
48 tests
£321,00
E-OSEL-H0084-48TESTS
96 tests
£388,00
E-OSEL-H0084-96TESTS
Über dieses Produkt
- SKU:
- E-OSEL-H0084
- Zusätzliche Namen:
- CD26,DPPIV,ADABP,ADCP2,TP103,Adenosine Deaminase Complexing Protein 2
- Anwendung:
- ELISA
- Weitere Details:
- Dipeptidyl Peptidase IV (DPPIV, also CD26 and adenosine deaminase complexing protein 2) is a serine protease that releases Xaa-Pro dipeptides from the N-terminus of oligo- and polypeptides. As a type II membrane protein, it includes a small cytoplasmic tail, a transmembrane region, and a large extracellular domain with glycosylation sites, a cysteine-rich region, and a Ser-Asp-His catalytic active site. Native DPPIV exists as a non-covalently linked homodimer on cell surfaces, with its soluble form (intact extracellular domain) present in human serum and other body fluids. DPPIV plays a key role in multiple physiological and pathological processes: it interacts with ADA and CD45 to co-stimulate the CD3/T-cell receptor complex, cleaves N-terminal Xaa-Pro-containing chemokines, altering their receptor specificity and function, degrades peptide hormones (e.g., glucagon-like peptide-1) to reduce bioactivity, with DPPIV inhibitors for type 2 diabetes in late-stage clinical trials, truncates procalcitonin (a marker for systemic bacterial/fungal infections), and interacts with HIV-1 Tat protein, whose ADA binding is inhibited by HIV envelope protein gp120.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Reichweite:
- 0.78-50 ng/mL
- Reaktivitäten:
- Human
- Empfindlichkeit:
- 0.47 ng/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:p-quickey_pro_human_dpp4_(dipeptidyl_peptidase_ⅳ)_elisa_kit-e_osel_h0084