Mini Sample Rat MIP-1A Alpha (Macrophage Inflammatory Protein 1 Alpha) ELISA Kit
Produktgrößen
24 tests
£143,00
E-MSEL-R0004-24TESTS
48 tests
£302,00
E-MSEL-R0004-48TESTS
96 tests
£365,00
E-MSEL-R0004-96TESTS
Über dieses Produkt
- SKU:
- E-MSEL-R0004
- Zusätzliche Namen:
- CCL3,LD78ALPHA,MIP-1-alpha,MIP1A,SCYA3,G0S19-1
- Anwendung:
- ELISA
- Weitere Details:
- CCL3, also known as macrophage inflammatory protein 1A Alpha (MIP-1A Alpha) and LD78, is a member of the chemokine beta or CC subfamily and is closely related to CCL4/ MIP-1B Beta. Chemokines include a large family of small secreted proteins involved in immune and inflammatory responses. CCL3 can be expressed in a variety of hematopoietic cells, fibroblasts, smooth muscle cells and epithelial cells. The amino acid sequence of CCL3 in mature rats showed 74%, 91% and 88% homology with that of human, mouse and cotton rats, respectively. CCL3 is a chemokine of about 8 kDa that forms complexes with sulfated proteoglycans. In a reversible process, CCL3 binds to non-covalently linked dimers, which then form tetramers and high molecular weight polymers. These complexes of CCL3 are not protected from proteolytic digestion by insulin-degrading enzymes (ides), which can cut monomer chemokines (6). CCL3 performs its biological functions through interactions with CCR1, CCR3, and CCR5. By inducing the internalization of the chemokine receptor D6, CCL3 is cleared from the extracellular space. And cell activation of many hematopoietic cell types, including activated T cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils. CCL3 is also known as a stem cell inhibitor (SCI), which inhibits the proliferation of hematopoietic progenitor cells (3). The biological activity of CCL3 contributes to tumor metastasis and the inflammatory components of viral infections, rheumatoid arthritis, and hepatitis, although it can also inhibit HIV replication. CCL3 also promotes hyperalgesia by sensitizing sensory neurons to trpv1 mediated harmful stimuli.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Reichweite:
- 15.63-1000 pg/mL
- Reaktivitäten:
- Rat
- Empfindlichkeit:
- 9.38 pg/mL
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Rat
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:p-mini_sample_rat_mip_1α_(macrophage_inflammatory_protein_1_alpha)_elisa_kit-e_msel_r0004