Mini Sample Mouse TNFRSF9 (Tumor Necrosis Factor Receptor Superfamily, Member 9) ELISA Kit
Produktgrößen
24 tests
£143,00
E-MSEL-M0120-24TESTS
48 tests
£302,00
E-MSEL-M0120-48TESTS
96 tests
£365,00
E-MSEL-M0120-96TESTS
Über dieses Produkt
- SKU:
- E-MSEL-M0120
- Zusätzliche Namen:
- CD137,CDw137,4-1BB,ILA,Induced By Lymphocyte Activation,T-cell antigen 4-1BB homolog
- Anwendung:
- ELISA
- Weitere Details:
- 4-1BB, also known as CD137 and ILA (induced by lymphocyte activation), is a TNF receptor superfamily member and has been designated TNFRSF9. Mouse 4-1BB cDNA encodes a 256 amino acid (aa) residues type I transmembrane protein with a putative 23 aa signal peptide, a 164 aa extracellular domain, a 21 aa transmembrane domain and a 48 aa cytoplasmic region (1-3). A soluble 4-1BB is released from surfaces of cells expressing the transmembrane protein (4). Mouse 4-1BB shares approximately 60% aa sequence identity with its human counterpart. 4-1BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also expressed on monocytes, neutrophils, DCs and eosinophils (5). The ligand for 4-1BB (4-1BBL), also named TNFSF9, belongs to the TNF ligand superfamily. 4-1BBL is predominantly expressed on activated antigen presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also expressed on most T and B lymphoma cell lines. In response to 4-1BBL binding, 4-1BB transduce a T cell costimulatory signal in both CD4+ and CD8+ T cells to promote survival and enhance proliferation, cytokine production and effector function. In vivo, the costimulatory activity of 4-1BB has been shown to be important in graft-vs-host disease and antiviral CTL responses. On dendritic cells, 4-1BB is a DC-activating molecules that enhances cytokine production and up-regulates expression of B7-1 and B7-2 costimulatory molecules, resulting in an improved ability to stimulate T cell responses (1-5).
- Format:
- Colorimetric method,ELISA,Sandwich
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Reichweite:
- 125-8000 pg/mL
- Reaktivitäten:
- Mouse
- Empfindlichkeit:
- 75 pg/mL
- Versandbedingungen:
- Blue Ice
- Spezifität:
- Mouse
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:p-mini_sample_mouse_tnfrsf9_(tumor_necrosis_factor_receptor_superfamily,_member_9)_elisa_kit-e_msel_m0120