Mini Sample Mouse IGFBP-3 (Insulin-like Growth Factor Binding Protein 3) ELISA Kit
Produktgrößen
24 tests
£143,00
E-MSEL-M0104-24TESTS
48 tests
£302,00
E-MSEL-M0104-48TESTS
96 tests
£365,00
E-MSEL-M0104-96TESTS
Über dieses Produkt
- SKU:
- E-MSEL-M0104
- Zusätzliche Namen:
- IGFBP3,BP-53,IBP3
- Anwendung:
- ELISA
- Weitere Details:
- The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth,differentiation,and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory,apoptosis-inducing molecule,capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism,where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signaling appears to require an active transforming growth factor-beta (TGF-beta) signaling pathway,and IGFBP3 stimulates phosphorylation of the TGF-beta signaling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor,retinoid X receptor (RXR)-alpha,and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer,prostate cancer,colorectal cancer,and lung cancer. Moreover,IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.
- Format:
- Colorimetric method,ELISA,Sandwich
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Reichweite:
- 78.13-5000 pg/mL
- Reaktivitäten:
- Mouse
- Empfindlichkeit:
- 46.88 pg/mL
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Typ:
- Assay Kits: ELISAs
- Datenblatt des Herstellers:p-mini_sample_mouse_igfbp_3_(insulin_like_growth_factor_binding_protein_3)_elisa_kit-e_msel_m0104