Human SIRT1 Antibody Pair Set
Produktgrößen
1 set
£882,00
E-KAB-0701-1SET
Über dieses Produkt
- SKU:
- E-KAB-0701
- Zusätzliche Namen:
- SIR2L1,NAD-dependent deacetylase sirtuin-1
- Anwendung:
- ELISA
- Buffer:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Weitere Details:
- SIRT1,the human homolog of the S. cerevisiae Sir2 protein,functions as an NAD-dependent deacetylase of a number of nonhistone substrates including p53. In response to DNA damage,SIRT1 binds and deacetylates the p53 protein at c-terminal Lys382 residue and attenuates p53-mediated functions. When overexpressed in mouse embryo fibroblasts,SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. In mammalian cells,SIRT1 appears to control the cellular response to stress by regulating the FOXO family of forkhead transcription factors.
- Format:
- Colorimetric method;ELISA;Sandwich
- Formulierung:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Immunogen:
- SIRT1
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Antibody Pair
- Datenblatt des Herstellers:p-human_sirt1_antibody_pair_set-e_kab_0701