Human HAVCR2 Antibody Pair Set
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1 set
£512,00
E-KAB-0437-1SET
Über dieses Produkt
- SKU:
- E-KAB-0437
- Zusätzliche Namen:
- T cell immunoglobulin and mucin domain containing protein 3,hepatitis virus cellular receptor 2,CD366
- Anwendung:
- ELISA
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Weitere Details:
- T cell immunoglobulin and mucin domain-3 ( TIM3 ) , also called hepatitis A virus cellular receptor 2 ( HAVCR2 ) , isa transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important rolein the Th1-mediated immune response. TIM3 is expressed on the Th1 cells , CD8 T-cells , monocytes , anddendritic cells , but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosisof apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interactionwith phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressivefunctions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with anagonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is alsoregarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 ( PD-1 ) as twoimportant coinhibitory regulators of T cell responses , have been implicated with the T-cell dysfunction orexhaustion associated with chronic HBV infection including HBV-related HCC.
- Format:
- Colorimetric method;ELISA;Sandwich
- Formulierung:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- HAVCR2
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Antibody Pair
- Datenblatt des Herstellers:p-human_havcr2_antibody_pair_set-e_kab_0437