Elab Fluor[R] 700 Anti-Mouse Foxp3 Antibody[3G3]
Produktgrößen
50 tests
£189,00
E-AB-F1238M1-50TESTS
100 tests
£270,00
E-AB-F1238M1-100TESTS
2 x 100 tests
£378,00
E-AB-F1238M1-2X100TESTS
Über dieses Produkt
- SKU:
- E-AB-F1238M1
- Zusätzliche Namen:
- Forkhead box protein P3;Foxp3;IPEX;JM2
- Anwendung:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- 3G3
- Klonalität:
- Monoclonal
- Konjugat:
- Elab Fluor® 700
- Weitere Details:
- Foxp3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of Foxp3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. Foxp3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of Foxp3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of Foxp3 have been reported: one (Foxp3) corresponding to the canonical full-length sequence; the other (Foxp3 D Delta2) lacking exon 2.
- Host:
- Mouse
- Immunogen:
- Foxp3
- Isotyp:
- IgG1, kappa
- Reaktivitäten:
- Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:p-elab_fluor®_700_anti_mouse_foxp3_antibody[3g3]-e_ab_f1238m1