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Antikörper

Purified Anti-Human CD279/PD-1 Antibody[J110], Functional Grade

Produktgrößen
100 ug
£89,00
E-AB-F12130-100UG
1 mg
£171,00
E-AB-F12130-1MG
5 mg
£490,00
E-AB-F12130-5MG
25 mg
£1515,00
E-AB-F12130-25MG
50 mg
£2247,00
E-AB-F12130-50MG
100 mg
£3211,00
E-AB-F12130-100MG
Über dieses Produkt
SKU:
E-AB-F12130
Zusätzliche Namen:
PD1,PDCD1,Protein PD-1,hPD-1
Anwendung:
Block/Inhibit/Neutralise, Flow Cytometry
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
J110
Klonalität:
Monoclonal
Konzentration:
>= 1 mg/ml
Weitere Details:
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
Host:
Mouse
Immunogen:
CD279/PD-1
Isotyp:
IgG1, kappa
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Hersteller:
Elabscience
Typ:
Antibody: Monoclonal Antibody
Monomer purity ≥95% as determined by analytical size-exclusion chromatography (SEC)
Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Human CD45RO Antibody[UCHL1](Right) and 0.2 ug Mouse IgG2a, K Kappa Isotype Control(Left), followed by APC-conjugated Goat Anti-Mouse IgG Secondary Antibody, then anti-Human CD45RA FITC-conjugated Monoclonal Antibody and anti-Human CD3 PerCP-conjugated Monoclonal Antibody. Data shown were from CD3+ population.
Human peripheral blood lymphocytes were activated for 6 hour with PMA+ ionomycin, then stained with 0.2 ug Purified Anti-Human CD69 Antibody[FN50] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control(Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood were stained with 0.2 ug Purified Anti-Human CD45 Antibody[HI30] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by FITC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse CD45 Antibody[30-F11] (Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor®647-conjugated Goat Anti-Rat IgG Secondary Antibody.