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Antikörper

AF/LE Purified Anti-Human IL-2 Antibody[MQ1-17H12]

Produktgrößen
25 ug
£66,00
E-AB-F12000-25UG
100 ug
£89,00
E-AB-F12000-100UG
1 mg
£171,00
E-AB-F12000-1MG
5 mg
£490,00
E-AB-F12000-5MG
25 mg
£1515,00
E-AB-F12000-25MG
50 mg
£2247,00
E-AB-F12000-50MG
100 mg
£3211,00
E-AB-F12000-100MG
Über dieses Produkt
SKU:
E-AB-F12000
Zusätzliche Namen:
IL2;IL-2;TCGF;lymphokine;Aldesleukin;IL-2lymphokine;interleukin-2;Proleukin;interleukin 2;involved in regulation of T-cell clonal expansion;T cell growth factor;T-cell growth factor;IL 2;IL2;Interleukin 2;interleukin2;Involved in regulation of T cell clonal expansion;Lymphokine;POIL2;T Cell Growth Factor;TCGF
Anwendung:
Flow Cytometry
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
MQ1-17H12
Klonalität:
Monoclonal
Konzentration:
>= 1 mg/ml
Weitere Details:
Interleukin-2 (IL-2) is a O-glycosylated, four alpha -helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma D Delta T cells, B cells, dendritic cells, and eosinophils. Mature human IL-2 shares 56% and 66% aa sequence identity with Mouse and Rat IL-2, respectively. Human and Mouse IL-2 exhibit cross-species activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to prolifeRate and induces IL-2 and IL-2 R alpha synthesis. It contributes to T cell homeostasis by promoting the Fas-induced death of naive CD4+ T cells but not activated CD4+ memory lymphocytes. IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity.
Host:
Rat
Immunogen:
IL-2|Recombinant Human IL-2 protein
Isotyp:
IgG2a, kappa
Reinheit:
>98%
Aufreinigung:
protein a/g purified
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Hersteller:
Elabscience
Typ:
Antibody: Monoclonal Antibody
  • Datenblatt des Herstellers:HtaH0C
C57/BL6 Mouse splenocytes were stained with 0.2 ug AF/LE Purified Anti-Mouse CD40 Antibody[FGK4.5/FGK45] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody, then anti-Mouse CD3 PE-conjugated Monoclonal Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse CD40 Antibody[FGK4.5/FGK45](Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control(Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody, then anti-Mouse CD3 PE-conjugated Monoclonal Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug AF/LE Purified Anti-Mouse CD122 Antibody[5H4] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by APC-conjugated Goat Anti-Rat IgG Secondary Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug Purified Anti-Mouse CD122 Antibody[5H4] (Right) and 0.2 ug Rat IgG2a, K Kappa Isotype Control (Left), followed by APC-conjugated Goat Anti-Rat IgG Secondary Antibody.