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Antikörper

AF/LE Purified Anti-Mouse IL-17A Antibody[TC11-18H10.1]

Produktgrößen
25 ug
£66,00
E-AB-F11990-25UG
100 ug
£89,00
E-AB-F11990-100UG
1 mg
£171,00
E-AB-F11990-1MG
5 mg
£490,00
E-AB-F11990-5MG
25 mg
£1515,00
E-AB-F11990-25MG
50 mg
£2247,00
E-AB-F11990-50MG
100 mg
£3211,00
E-AB-F11990-100MG
Über dieses Produkt
SKU:
E-AB-F11990
Zusätzliche Namen:
IL-17CTLA;Cytotoxic T-lymphocyte-associated antigen;IL-17Acytotoxic T-lymphocyte-associated protein;CTLA8cytotoxic T-lymphocyte-associated serine esterase;CTLA 8;CTLA8cytotoxic T-lymphocyte-associated serine esterase 8;Ctla9;IL-17A;IL-17Acytotoxic T-lymphocyte-associated protein 8;IL-17CTLA-8;Interleukin-17A;IL-17;CTLA-8;Il17a;Cytotoxic T-lymphocyte-associated antigen 8;Ctla8;Il17;CTLA8;CTLA-8;CTLA8cytotoxic T-lymphocyte-associated serine esterase 8;Cytotoxic T-lymphocyte-associated antigen 8;IL17;IL-17;IL17A;IL-17A;IL-17Acytotoxic T-lymphocyte-associated protein 8;IL-17CTLA-8
Anwendung:
Flow Cytometry
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
TC11-18H10.1
Klonalität:
Monoclonal
Konzentration:
>= 1 mg/ml
Weitere Details:
Interleukin-17A (IL-17A), also known as CTLA-8, is a 15-20 kDa glycosylated cytokine that plays an important role in anti-microbial and chronic inflammation. The six IL-17 cytokines (IL-17A-F) are encoded by separate genes but adopt a conserved cystine knot fold. Mature rat IL-17A shares 60% and 89% amino acid sequence identity with human and mouse IL-17A, respectively. IL-17A is secreted by Th17 cells, gamma /D Delta T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. It forms disulfide-linked homodimers as well as disulfide-linked heterodimers with IL-17F. IL-17A exerts its effects through the transmembrane IL-17RA in complex with IL-17RC or IL-17RD. Both IL-17RA and IL-17RC are required for responsiveness to heterodimeric IL-17A/F. IL-17A promotes protective mucosal and epidermal inflammation in response to microbial infection. It induces chemokine production, neutrophil influx, and the production of antibacterial peptides. IL-17A/F likewise induces neutrophil migration, but IL-17F does not. IL-17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF-alpha induced shock. In contrast, it can protect against the progression of colitis by limiting chronic inflammation. IL-17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity. IL-17A has been shown to exert either tumorigenic or anti-tumor effects.
Host:
Rat
Immunogen:
IL-17A|Recombinant Mouse IL-17A protein
Isotyp:
IgG1, kappa
Reinheit:
>98%
Aufreinigung:
protein a/g purified
Reaktivitäten:
Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Hersteller:
Elabscience
Typ:
Antibody: Monoclonal Antibody
  • Datenblatt des Herstellers:Dliy10
Rat splenocytes were stained with 0.2 ug Purified Anti-Human/Mouse/Rat CD47 Antibody[MIAP410] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by FITC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug AF/LE Purified Anti-Mouse CD54 Antibody[YN1/1.7.4] (Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse CD48 Antibody[HM48-1] (Right) and 0.2 ug Armenian Hamster IgG, K Kappa Isotype Control (Left), followed by PE-conjugated Goat Anti-Armenian Hamster IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug Purified Anti-Mouse CD54 Antibody[YN1/1.7.4](Right) and 0.2 ug Rat IgG2b, K Kappa Isotype Control(Left), followed by Elab Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody.
C57/BL6 Mouse splenocytes were stained with 0.2 ug AF/LE Purified Anti-Mouse CD48 Antibody[HM48-1] (Right) and 0.2 ug Armenian Hamster IgG, K Kappa Isotype Control (Left), followed by PE-conjugated Goat Anti-Armenian Hamster IgG Secondary Antibody.