APC Anti-Human CD196/CCR6 Antibody[G034E3]
Produktgrößen
20 tests
£131,00
E-AB-F1158E-20TESTS
100 tests
£291,00
E-AB-F1158E-100TESTS
2 x 100 tests
£411,00
E-AB-F1158E-2X100TESTS
Über dieses Produkt
- SKU:
- E-AB-F1158E
- Zusätzliche Namen:
- CMKBR6;GPR29;STRL22;CKRL3;GPRCY4;CCR6
- Anwendung:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- G034E3
- Klonalität:
- Monoclonal
- Konjugat:
- APC
- Konzentration:
- 5 ul/test
- Weitere Details:
- CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the B Beta defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
- Host:
- Mouse
- Immunogen:
- CD196/CCR6
- Isotyp:
- IgG2b, kappa
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:ccr6_antibody[g034e3]-e_ab_f1158e