KIR2DL3 Polyclonal Antibody
Produktgrößen
60 ul
£217,00
E-AB-60414-60UL
120 ul
£317,00
E-AB-60414-120UL
200 ul
£492,00
E-AB-60414-200UL
Über dieses Produkt
- SKU:
- E-AB-60414
- Zusätzliche Namen:
- CD158B2,CD158b,GL183,KIR-023GB,KIR-K7b,KIR-K7c,KIR2DL3,KIR2DS5,KIRCL23,NKAT,NKAT2,NKAT2A,NKAT2B,p58
- Anwendung:
- Immunofluorescence, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
- Host:
- Rabbit
- Immunogen:
- Recombinant fusion protein of human KIR2DL3 (NP_056952.2).
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-kir2dl3_polyclonal_antibody-e_ab_60414