XAB2 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-53550-20UL
60 ul
£183,00
E-AB-53550-60UL
120 ul
£272,00
E-AB-53550-120UL
200 ul
£420,00
E-AB-53550-200UL
Über dieses Produkt
- SKU:
- E-AB-53550
- Zusätzliche Namen:
- 0610041O14Rik,AV025587,Adapter protein ATH-55,Ath55,Crn related protein kim1 ,DKFZp762C1015,HCNP,HCNP protein,HCRN,KIAA1177,NTC90,PP3898,Pre-mRNA-splicing factor SYF1,Protein HCNP,RNA splicing factor,SY,SYF1,adapter protein ATH 55,crn-related protein kim1
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.4 mg/ml
- Weitere Details:
- HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human XAB2
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-xab2_polyclonal_antibody-e_ab_53550