EIF3C Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-52777-20UL
60 ul
£183,00
E-AB-52777-60UL
120 ul
£272,00
E-AB-52777-120UL
200 ul
£420,00
E-AB-52777-200UL
Über dieses Produkt
- SKU:
- E-AB-52777
- Zusätzliche Namen:
- Cell migration inducing protein 17;EIF3C;EIF3CL;EIF3S8;EIF3S8 protein;Eukaryotic translation initiati;Eukaryotic translation initiation factor 3 subunit 8 (110kD);Eukaryotic translation initiation factor 3 subunit 8 110kDa;eIF 3c;eIF3 p110;eIF3-p110;eIF3c
- Anwendung:
- Immunohistochemistry
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 0.6 mg/ml
- Weitere Details:
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human EIF3C
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-eif3c_polyclonal_antibody-e_ab_52777