Phospho-SMAD3 (Ser425) Monoclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-51043-20UL
60 ul
£183,00
E-AB-51043-60UL
120 ul
£272,00
E-AB-51043-120UL
200 ul
£420,00
E-AB-51043-200UL
Über dieses Produkt
- SKU:
- E-AB-51043
- Zusätzliche Namen:
- DKFZP586N0721,DKFZp686J10186,HSPC193,HST17436,JV15 2,JV15-2,JV152,LDS1C,LDS3,MAD,MAD (mothers against decapentaplegic Drosophila) homolog 3,MAD homolog 3,Mad homolog JV15 2,Mad protein homolog,hMAD 3,hMAD-3,hSMAD3,mothers against decapentaplegic homolog 3
- Anwendung:
- IHC-Paraffin, Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- translate.label.attr.clone:
- 4C5
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
- Host:
- Mouse
- Immunogen:
- Synthetic Peptide of Phospho-Smad3 (Ser425)
- Isotyp:
- IgG
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:p-phospho_smad3_(ser425)_monoclonal_antibody-e_ab_51043