DNA-RNA Hybrid Monoclonal Antibody[S9.6]
Produktgrößen
25 ul
£134,00
E-AB-48028-25UL
100 ul
£291,00
E-AB-48028-100UL
Über dieses Produkt
- SKU:
- E-AB-48028
- Zusätzliche Namen:
- DNA-RNA hybrid;RNA/DNA hybrid
- Anwendung:
- ChIP, Immunofluorescence
- Buffer:
- PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
- translate.label.attr.clone:
- S9.6
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNA?RNA hybrids but also binds RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and structural dependency since R?loop sequence affects binding affinity.
- Host:
- Mouse
- Immunogen:
- F PhiX174 bacteriophage-derived synthetic DNA/RNA
- Isotyp:
- IgG2a
- Aufreinigung:
- Protein A/G Purification
- Reaktivitäten:
- Wide/Non-species Specific
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Monoclonal Antibody
- Datenblatt des Herstellers:p-dna_rna_hybrid_monoclonal_antibody[s9.6]-e_ab_48028