PLN Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-19885-20UL
60 ul
£183,00
E-AB-19885-60UL
120 ul
£272,00
E-AB-19885-120UL
200 ul
£420,00
E-AB-19885-200UL
Über dieses Produkt
- SKU:
- E-AB-19885
- Zusätzliche Namen:
- CMD1P,CMH18,Cardiac phospholamban,PLB,PPLA,Pln
- Anwendung:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Klonalität:
- Polyclonal
- Konzentration:
- 1.26 mg/ml
- Weitere Details:
- The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human PLN
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-pln_polyclonal_antibody-e_ab_19885