CBFA2T2 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-19075-20UL
60 ul
£183,00
E-AB-19075-60UL
120 ul
£272,00
E-AB-19075-120UL
200 ul
£420,00
E-AB-19075-200UL
Über dieses Produkt
- SKU:
- E-AB-19075
- Zusätzliche Namen:
- alpha subunit 2, runt domain,AML1 MTG8,Core binding factor runt domain alpha subunit 2 translocated to 2,DKFZp313F2116,EHT,ETO homolog on chromosome 20,ETO homologous on chromosome 20,MTG 8 like protein,MTG 8 related protein 1,cbfa2t2,core-binding factor
- Anwendung:
- Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Klonalität:
- Polyclonal
- Konzentration:
- 1.26 mg/ml
- Weitere Details:
- In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human CBFA2T2
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-cbfa2t2_polyclonal_antibody-e_ab_19075