BCAS3 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-18703-20UL
60 ul
£183,00
E-AB-18703-60UL
120 ul
£272,00
E-AB-18703-120UL
200 ul
£420,00
E-AB-18703-200UL
Über dieses Produkt
- SKU:
- E-AB-18703
- Zusätzliche Namen:
- 1500019F07Rik;2610028P08Rik;AU021018;BC028339;BCAS3;Breast carcinoma-amplified sequence 3;FLJ20128;GAOB1;K20D4;MAAB;MGC4973;Maab1 protein;rudhira
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 1.26 mg/ml
- Weitere Details:
- BCAS3 (breast carcinoma amplified sequence 3), also designated MAAB or GAOB1, is a 913 amino acid protein that is believed to be involved in breast cancer progression. The gene is regulated by ER (estrogen receptor alpha) and expressed in multiple tissues, including malignant human brain lesions. It is overexpressed and amplified in breast cancer cell lines. BCAS3 contains three WD40 repeat regions, a bromodomain, a rare zinc-finger motif, four probable DNA-binding domains, and two kinase-inducible phosphorylation domains. Five variants are produced due to alternative splicing. BCAS3 interacts with histone H3 and PCAF, which is indicative of histone acetyltransferase activity. BCAS3 also exhibits ER transactiviation activity by acting as a coactivator with PELP1 or MTA1. The amplification and translocation between the BCAS3 gene and the BCAS4 gene results in a fusion transcript is overexpressed in MCF-7 cells.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human BCAS3
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-bcas3_polyclonal_antibody-e_ab_18703