IMPA1 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-18668-20UL
60 ul
£183,00
E-AB-18668-60UL
120 ul
£272,00
E-AB-18668-120UL
200 ul
£420,00
E-AB-18668-200UL
Über dieses Produkt
- SKU:
- E-AB-18668
- Zusätzliche Namen:
- IMP,IMP 1,IMPA,IMPA 1,IMPA1,IMPase,IMPase 1,Inositol 1(or 4) monophosphatase,Inositol monophosphatase,Inositol monophosphatase 1,Inositol(myo) 1(or 4) monophosphatase 1,Inositol-1(or 4)-monophosphatase 1,Lithium sensitive myo inositol monophosphatas
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.9 mg/ml
- Weitere Details:
- This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
- Host:
- Rabbit
- Immunogen:
- Fusion protein of human IMPA1
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-impa1_polyclonal_antibody-e_ab_18668