HLA-DOB Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-18081-20UL
60 ul
£183,00
E-AB-18081-60UL
120 ul
£272,00
E-AB-18081-120UL
200 ul
£420,00
E-AB-18081-200UL
Über dieses Produkt
- SKU:
- E-AB-18081
- Zusätzliche Namen:
- DO beta chain;HLA class II histocompatibility antigen;HLA-DOB;MHC class II antigen DOB
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 1.2 mg/ml
- Weitere Details:
- HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human HLA-DOB
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-hla_dob_polyclonal_antibody-e_ab_18081