ERN2 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-16413-20UL
60 ul
£183,00
E-AB-16413-60UL
120 ul
£272,00
E-AB-16413-120UL
200 ul
£420,00
E-AB-16413-200UL
Über dieses Produkt
- SKU:
- E-AB-16413
- Zusätzliche Namen:
- IRE1-BETA;IRE1b
- Anwendung:
- Immunohistochemistry
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 1.1 mg/ml
- Weitere Details:
- The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1A Alpha and IRE1B Beta are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human ERN2
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-ern2_polyclonal_antibody-e_ab_16413