CUL2 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-15575-20UL
60 ul
£183,00
E-AB-15575-60UL
120 ul
£272,00
E-AB-15575-120UL
200 ul
£420,00
E-AB-15575-200UL
Über dieses Produkt
- SKU:
- E-AB-15575
- Zusätzliche Namen:
- CUL 2;CUL-2;CUL2;Cul2;Cullin-2;MGC131970;cullin 2;cullin homolog 2
- Anwendung:
- Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 0.6 mg/ml
- Weitere Details:
- Human CUL2 is an ortholog of nematode cul2. Michel and Xiong (1998) identified human CUL2 cDNAs and reported that the predicted protein is 745 amino acids long.Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, whicHuman, Mouseediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human CUL2
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-cul2_polyclonal_antibody-e_ab_15575