DAB2 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-14925-20UL
60 ul
£183,00
E-AB-14925-60UL
120 ul
£272,00
E-AB-14925-120UL
200 ul
£420,00
E-AB-14925-200UL
Über dieses Produkt
- SKU:
- E-AB-14925
- Zusätzliche Namen:
- DAB 2;DAB2;Dab;Differentially expressed in ovarian cancer 2;Differentially expressed protein 2;Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein);Disabled homolog;Disabled homolog 2;homolog 2 (Drosophila);mitogen-responsive phosphoprotein
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 0.6 mg/ml
- Weitere Details:
- This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human DAB2
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-dab2_polyclonal_antibody-e_ab_14925