COX10 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-13841-20UL
60 ul
£183,00
E-AB-13841-60UL
120 ul
£272,00
E-AB-13841-120UL
200 ul
£420,00
E-AB-13841-200UL
Über dieses Produkt
- SKU:
- E-AB-13841
- Zusätzliche Namen:
- 2410004F01Rik;AU042636;COX10;Cytochrome c oxidase assembly protein;Cytochrome c oxidase subunit X;Heme A farnesyltransferase;Heme O synthase;OTTMUSP00000006085;Protoheme IX farnesyltransferase;mitochond;mitochondrial
- Anwendung:
- Immunohistochemistry
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 0.4 mg/ml
- Weitere Details:
- Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human COX10
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-cox10_polyclonal_antibody-e_ab_13841