FAS Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-13830-20UL
60 ul
£183,00
E-AB-13830-60UL
120 ul
£272,00
E-AB-13830-120UL
200 ul
£420,00
E-AB-13830-200UL
Über dieses Produkt
- SKU:
- E-AB-13830
- Zusätzliche Namen:
- ALPS 1A;ALPS1A;APO 1;APO 1 cell surface antigen;APO1;APO1 cell surface antigen;APT 1;APT1;Apo 1 antigen;Apo-1 antigen;Apo1 antigen;Apoptosis antigen 1;Apoptosis mediating surface antigen FAS;Apoptosis-mediating surface antigen FAS;CD 95;CD 95 antigen;CD95
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 0.4 mg/ml
- Weitere Details:
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human FAS
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-fas_polyclonal_antibody-e_ab_13830