DUT Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-12372-20UL
60 ul
£183,00
E-AB-12372-60UL
120 ul
£272,00
E-AB-12372-120UL
200 ul
£420,00
E-AB-12372-200UL
Über dieses Produkt
- SKU:
- E-AB-12372
- Zusätzliche Namen:
- DUT;Deoxyuridine 5' triphosphate nucleotidohydrolase;Deoxyuridine 5'-triphosphate nucleotidohydrolase;Deoxyuridine triphosphatase;FLJ20622;dUTP nucleotidohydrolase;dUTP pyrophosphatase;dUTPase;dut;mitochondrial;nuclear isoform
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 0.2 mg/ml
- Weitere Details:
- This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide of human DUT
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-dut_polyclonal_antibody-e_ab_12372