ERCC6L Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-11196-20UL
60 ul
£183,00
E-AB-11196-60UL
120 ul
£272,00
E-AB-11196-120UL
200 ul
£420,00
E-AB-11196-200UL
Über dieses Produkt
- SKU:
- E-AB-11196
- Zusätzliche Namen:
- ATP dependent helicase ERCC6 like;ATP-dependent helicase ERCC6-like;DNA excision repair protein ERCC 6 like;DNA excision repair protein ERCC-6-like;ERC6L;ERCC 6L;Ercc6l;Excision repair cross complementing rodent repair deficiency complementation group 6 l
- Anwendung:
- Immunohistochemistry
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human ERCC6L
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-ercc6l_polyclonal_antibody-e_ab_11196