pVHL Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-10671-20UL
60 ul
£183,00
E-AB-10671-60UL
120 ul
£272,00
E-AB-10671-120UL
200 ul
£420,00
E-AB-10671-200UL
Über dieses Produkt
- SKU:
- E-AB-10671
- Zusätzliche Namen:
- E3 ubiquitin pro,Elongin binding protein,G7 protein,HRCA 1,HRCA1,Protein G7,RCA 1,RCA1,VHL,VHL 1,VHL1,VHLH,Von Hippel Lindau disease tumor suppressor,Von Hippel Lindau tumor suppressor,pVHL,von Hippel Lindau syndrome,von Hippel Lindau tumor suppressor
- Anwendung:
- Immunohistochemistry
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Klonalität:
- Polyclonal
- Konzentration:
- 0.4 mg/ml
- Weitere Details:
- Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human VHL
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-pvhl_polyclonal_antibody-e_ab_10671