BRCA1 Polyclonal Antibody
Produktgrößen
20 ul
£118,00
E-AB-10188-20UL
60 ul
£183,00
E-AB-10188-60UL
120 ul
£272,00
E-AB-10188-120UL
200 ul
£420,00
E-AB-10188-200UL
Über dieses Produkt
- SKU:
- E-AB-10188
- Zusätzliche Namen:
- BRCA 1;BRCA1;BRCA1 DNA repair associated;BRCA1/BRCA2 containing complex subunit 1;BRCA1/BRCA2-containing complex;BRCAI;BRCC 1;BRCC1;Breast Cancer 1;Breast Cancer 1 Early Onset;Breast and ovarian cancer susceptibility protein 1;Breast cance;subunit 1
- Anwendung:
- Immunohistochemistry
- Buffer:
- PBS
- Klonalität:
- Polyclonal
- Konzentration:
- 0.3 mg/ml
- Weitere Details:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human BRCA1
- Isotyp:
- IgG
- Aufreinigung:
- Affinity Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Polyclonal Antibody
- Datenblatt des Herstellers:p-brca1_polyclonal_antibody-e_ab_10188