Recombinant Phospho-Smad2 (S255) Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN302094L-50UL
100 ul
£402,00
AN302094L-100UL
Über dieses Produkt
- SKU:
- AN302094L
- Zusätzliche Namen:
- MADH,MADR,hMAD,SMAD,hSMAD,JV18,JV18-1,MADH2,MADR2,hMAD-2,hSMAD2,Smad2,Drosophila,homolog of,hSMAD family member 2,JV181,MAD,MAD homolog 2,MAD Related Protein 2,Mad-related protein 2,MGC22139,MGC34440,Mother against DPP homolog 2,Mothers against decapentaplegic,Mothers against decapentaplegic homolog 2,Mothers against DPP homolog 2,OTTHUMP00000163489,Sma and Mad related protein 2,Sma- and Mad-related protein 2 MAD,SMAD 2,SMAD family member 2
- Anwendung:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A818
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- SMAD2, also named as MADH2 and MADR2, belongs to the dwarfin/SMAD family, contains 1 MH1 (MAD homology 1) domain and 1 MH2 (MAD homology 2) domain. SMAD2 is a receptor-regulated SMAD(R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. This protein may act as a tumor suppressor in colorectal carcinoma. It is phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, It is phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases, and then able to interact with SMURF2, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, it is phosphorylated on Ser-240 by CaMK2. It is phosphorylated by MAPK3 upon EGF stimulation, which increases transcriptional activity and stability, and is blocked by calmodulin.
- Host:
- Rabbit
- Immunogen:
- Recombinant Smad2 (phospho S255) fragment
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:p-recombinant_phospho_smad2_(s255)_monoclonal_antibody-an302094l