Recombinant TRIAD1 Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN302043L-50UL
100 ul
£402,00
AN302043L-100UL
Über dieses Produkt
- SKU:
- AN302043L
- Zusätzliche Namen:
- ARI,ARIH,TRIAD,ARI2,TRIAD1,ARIH2,HT005,all trans retinoic acid inducible RING finger,Ari 2,Ari-2,Ariadne 2,Ariadne 2 protein homolog,ariadne homolog 2,ariadne homolog 2 (Drosophila),Ariadne RBR E3 ubiquitin protein ligase 2,ARIH 2,E3 ubiquitin protein ligase ARIH2,E3 ubiquitin-protein ligase ARIH2,protein ariadne 2 homolog,Protein ariadne-2 homolog,Triad 1,Triad1 protein,UIP48
- Anwendung:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A763
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The E3 ubiquitin-protein ligase ARIH2 (TRIAD1) is an Ariadne subfamily ligase involved in the polyubiquitination of proteins designated for proteasomal degradation. The TRIAD1 nuclear protein contains an amino-terminal acidic region, a pair of RING fingers, two carboxyl terminal coiled coil domains and a novel C6HC DRIL/IBR domain located between the RING fingers. Together, the paired RING fingers and DRIL/IBR domain form a highly conserved TRIAD (two RING fingers and DRIL) domain. Research studies suggest that TRIAD1 mediates both Lys48 and Lys63 protein polyubiquitination and acts as a negative regulator of myelopoiesis. TRIAD1 ubiquitin ligase inhibits myeloid cell proliferation by mediating protein ubiquitination through the ubiquitin-conjugating enzymes UbcH7 and UbcH13. Experimental deletion of TRIAD1 in mice has a lethal effect, leading to death at the embryonic stage or later due to a severe, multi-organ inflammatory response. Results indicate that TRIAD1 binds IK KappaBB Beta in dendritic cells and promotes the degradation of the NF-K KappaB inhibitor.
- Host:
- Rabbit
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:p-recombinant_triad1_monoclonal_antibody-an302043l