Recombinant RON Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN302001L-50UL
100 ul
£402,00
AN302001L-100UL
Über dieses Produkt
- SKU:
- AN302001L
- Zusätzliche Namen:
- PTK,CDw,CD136,CDw136,PTK8,RON,MST1R,MSP-R,RON,CDw136
- Anwendung:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A721
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa A Alpha chain and a 150 kDa B Beta chain. Ron is initially synthesized in the cells as a single-chain, pro Ron precursor that is cleaved into the two active chains. The A Alpha chain is completely extracellular, whereas the B Beta chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements. Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis.The signaling pathways activated downstream of Ron include the ras/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K)/Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis and survival. The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors.
- Host:
- Rabbit
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:p-recombinant_ron_monoclonal_antibody-an302001l