Recombinant MASH1 Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN301998L-50UL
100 ul
£402,00
AN301998L-100UL
Über dieses Produkt
- SKU:
- AN301998L
- Zusätzliche Namen:
- ASH,ASCL,HASH,MASH,bHLHa,ASCL1,ASH1,HASH1,MASH1,bHLHa46,Achaete scute complex homolog 1,Achaete scute complex homolog like 1,Achaete scute complex homologue 1,Achaete scute complex homologue like 1,Achaete scute complex like 1,Achaete scute family bHLH transcription factor 1,Achaete scute protein,Achaete-scute homolog 1,Ascl 1,Ash 1,ASH-1,Class A basic helix-loop-helix protein 46,Hash 1,Mammalian achaete scute homolog 1,Mammalian achaete scute homologue 1,Mash 1
- Anwendung:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A718
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- MASH1, also known as achaete-scute homolog 1 (ASCL1), is a basic helix-loop-helix (BHLH) transcription factor which plays an essential role in the differentiation of neuroendocrine cells and neural tissues. MASH1 directly binds the E-box motif (5'-CANNTG-3') on promoters, with dimerization with other BHLH proteins required for efficient DNA binding. Acting as a pioneer transcription factor, MASH1 also accesses closed chromatin, allowing other factors to promote transcription of neuronal genes and activate neural pathways. Research studies have shown that knockdown of the MASH1 gene leads to inhibition of growth and induction of apoptosis in SCLC cells in vitro. Additionally, MASH1 is overexpressed in both classic SCLC as well as NSCLC with neuroendocrine features, suggesting its role in the pathogenesis of those malignancies. MASH1 plays a crucial role in promoting SCLC carcinogenesis by upregulating the expression of DLL3, a nonfunctioning Notch ligand, leading to inhibition of the Notch signaling pathway.
- Host:
- Rabbit
- Immunogen:
- Peptide. This information is proprietary to PTMab
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:p-recombinant_mash1_monoclonal_antibody-an301998l