Recombinant DcR1 Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN301996L-50UL
100 ul
£402,00
AN301996L-100UL
Über dieses Produkt
- SKU:
- AN301996L
- Zusätzliche Namen:
- DCR,UNQ,PRO,TRAILR,TRAIL-R,TNFRSF10C,CD263,DCR1,DCR1-TNFR,LIT,TRAIL-R3,TRAILR3,TRID,UNQ321,PRO366,DcR1,TRID,TNFRSF10c,Antagonist Decoy Receptor for TRAIL/Apo-2L,Decoy Receptor 1,Decoy TRAIL Receptor Without Death Domain,Lymphocyte Inhibitor of TRAIL,TNF-Related Apoptosis-Inducing Ligand Receptor 3,TRAIL Receptor 3,TRAIL Receptor Without an Intracellular Domain,Tumor Necrosis Factor Receptor Superfamily Member 10C
- Anwendung:
- Immunofluorescence, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A716
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems.The receptors are activated by a family of cytokines that include TNF, FasL, and TNF-related apoptosis-inducing ligand (TRAIL). They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2, and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity.
- Host:
- Rabbit
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:p-recombinant_dcr1_monoclonal_antibody-an301996l