Recombinant CHD1 Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN301930L-50UL
100 ul
£402,00
AN301930L-100UL
Über dieses Produkt
- SKU:
- AN301930L
- Zusätzliche Namen:
- CHD,chromodomain-helicase-DNA-binding protein,CHD1,chromodomain-helicase-DNA-binding protein 1
- Anwendung:
- Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A646
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- CHD1 belongs to the SNF2/RAD54 helicase family. CHD1 is an aTP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. CHD1 regulates polymerase II transcription. It is required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. CHD1 negatively regulates DNA replication. CHD1 is associated with histone deacetylase (HDAC) activity. CHD1 is required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. It functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. It is required for maintaining open chromatin and pluripotency in embryonic stem cells. In PTEN-deficient prostate and breast cancers, CHD1 depletion profoundly and specifically suppressed cell proliferation, cell survival and tumorigenic potential.
- Host:
- Rabbit
- Immunogen:
- Recombinant human CHD1 fragment
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:p-recombinant_chd1_monoclonal_antibody-an301930l