Recombinant SLC7A5/LAT1 Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN301897L-50UL
100 ul
£402,00
AN301897L-100UL
Über dieses Produkt
- SKU:
- AN301897L
- Zusätzliche Namen:
- LAT,MPE,hLAT,SLC7A,SLC7A5,4F2LC,CD98,D16S469E,E16,LAT1,MPE16,hLAT1,CD98LC
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A613
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- L-type amino acid transporter 1 (LAT1), also known as Solute carrier family 7 member 5 (SLC7A5), is a high-affinity neutral transporter of larger amino acids. It facilitates the cellular amino acid uptake in a sodium independent manner and selectively transports D-and L-isomers of small neutral amino acids. LAT1 also regulates amino acid exchange in conjunction with solute carrier family 1 member 5 (SLC1A5). Transport of thyroid hormones across the placenta is established via LAT1 during normal fetal development. LAT1 promotes neuronal cell proliferation by regulating the transport of amino acids across the blood brain barrier. LAT1 is upregulated in various cancer types including breast cancer, lung cancer, prostate cancer, and gliomas. High expression of LAT1 is detected in non-small cell lung cancer with lymph node metastases. Increased LAT1 expression is a novel biomarker of high-grade malignancy in prostate cancers. Inhibition of LAT1 suppresses tumor cell growth in several tumor types.
- Host:
- Rabbit
- Immunogen:
- Recombinant human SLC7A5/LAT1 fragment
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:lat1_monoclonal_antibody-an301897l