Recombinant Smac/Diablo Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN301658L-50UL
100 ul
£402,00
AN301658L-100UL
Über dieses Produkt
- SKU:
- AN301658L
- Zusätzliche Namen:
- DFNA,DIABLO,DFNA64,SMAC,0610041G12Rik,DBLOH,DBOH,Diablo homolog,Diablo homolog (Drosophila),Diablo homolog mitochondrial,Diablo IAP binding mitochondrial protein,Diablo like protein,DIABLO S,Direct IAP binding protein with low pI,Direct IAP-binding protein with low pI,FLJ10537,FLJ25049,mitochondrial,Mitochondrial Smac protein,Second mitochondria derived activator of caspase,Second mitochondria-derived activator of caspase,SMAC 3,Smac protein,SMAC3
- Anwendung:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A361
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
- Host:
- Rabbit
- Immunogen:
- Recombinant human Smac/Diablo fragment
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:diablo_monoclonal_antibody-an301658l