Recombinant Cyclin D3 Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN301504L-50UL
100 ul
£402,00
AN301504L-100UL
Über dieses Produkt
- SKU:
- AN301504L
- Zusätzliche Namen:
- G1 S specific cyclin D,G1/S specific cyclin D,G1/S-specific cyclin-D,CyclinD,cyclin D,CCND3,cyclin D3,CCND 3,CyclinD3,D3 type cyclin,G1 S specific cyclin D3,G1/S specific cyclin D3,G1/S-specific cyclin-D3
- Anwendung:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A203
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Host:
- Rabbit
- Immunogen:
- Recombinant human Cyclin D3 fragment
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:p-recombinant_cyclin_d3_monoclonal_antibody-an301504l