Recombinant PD1 Monoclonal Antibody
Produktgrößen
50 ul
£281,00
AN301420L-50UL
100 ul
£402,00
AN301420L-100UL
Über dieses Produkt
- SKU:
- AN301420L
- Zusätzliche Namen:
- SLEB,hSLE,Programmed Death,programmed cell death,Programmed cell death protein,Systemic lupus erythematosus susceptibility,hPD,PDCD1,CD279,PD-1,PD1,SLEB2,hPD-1,hPD-l,hSLE1,programmed cell death 1,PD 1,CD279 antigen,hPD 1,hPD l,PDCD 1,Programmed cell death 1 protein,Programmed Death-1,Protein PD 1,Protein PD-1,Systemic lupus erythematosus susceptibility 2,Programmed cell death protein 1,CD279,CD279 antigen,hPD 1,hPD l,hPD-1,hSLE1,PD 1,PD-1,PD1,PDCD 1,PDCD1,PDCD1,Programmed cell death 1,Programmed cell death 1 protein,Programmed cell death protein 1,Protein PD 1,Protein PD-1,SLEB2,Systemic lupus erythematosus susceptibility 2
- Anwendung:
- Immunofluorescence, Immunohistochemistry
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- translate.label.attr.clone:
- A115
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The programmed cell death 1 protein (PD1) is an inhibitory receptor expressed on antigen activated T-cells that plays a critical role in the induction and maintenance of immune tolerance to self-antigens. Upon binding to its ligands CD274/PDCD1L1 (PD-L1) and CD273/PDCD1LG2 (PD-L2), PD1 is phosphorylated within its immunoreceptor tyrosine-based switch motif (ITSM), which facilitates the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2. PTPN11/SHP-2 then dephosphorylates key T-cell receptor (TCR) proximal signaling molecules, including ZAP70, PRKCQ/PKC theta and CD247/CD3 zeta, leading to the direct inhibition of T-cell activation. The PD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and evade destruction by the immune system, thereby facilitating tumor survival.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide derived from the human PD1 protein
- Isotyp:
- IgG, kappa
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:p-recombinant_pd1_monoclonal_antibody-an301420l