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Antikörper

Recombinant Histone H3 (Acetyl Lys64) Monoclonal Antibody

Produktgrößen
50 ul
£281,00
AN301413L-50UL
100 ul
£402,00
AN301413L-100UL
Über dieses Produkt
SKU:
AN301413L
Zusätzliche Namen:
Histone H,H3C,H3/A,H3C2,H3C3,H3C4,H3C6,H3C7,H3C8,H3FA,H3C10,H3C11,H3C12,HIST1H3A,H3C1,Histone H3.1,Histone H3/a,Histone H3/b,H3FL,HIST1H3B,H3FC,HIST1H3C,H3FB,HIST1H3D,H3FD,HIST1H3E,H3FI,HIST1H3F,H3FH,HIST1H3G,H3FK,HIST1H3H,H3FF,HIST1H3I,H3FJ,HIST1H3J,H3/A,H3FA,H3FB,H3FC,H3FD,H3FF,H3FH,H3FI,H3FJ,H3FK,H3FL,Hist1h3a,HIST1H3B,HIST1H3C,HIST1H3D,HIST1H3E,HIST1H3F,HIST1H3G,HIST1H3H,HIST1H3I,HIST1H3J,Histone H3.1,Histone H3/a,Histone H3/b,H3 histone family,H31,H3a,histone 1,Histone cluster 1,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l,member A
Anwendung:
ChIP, Immunohistochemistry, Western Blot
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
translate.label.attr.clone:
A108
Klonalität:
Recombinant Monoclonal
Konzentration:
1 mg/ml
Weitere Details:
Histone post-translational modifications (PTMs), known as the "histone code", are key mechanisms of epigenetics that modulate chromatin structures. The PTMs on histone including acetylation, methylation, phosphorylation, and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability and gene transcription. Histone acetylation, tightly controlled by the opposing action of histone acetyltransferases (HATs) and histone deacetylases (HDACs), occurs primarily at lysine residues on the N-terminal tails of histones H2A (Lys5, 9, and 15), H2B (Lys5, 12, 15, 16, and 20), H3 (Lys4, 9, 14, 18, 23, 27, and 36), and H4 (Lys5, 8, 12, 16, and 20), and plays vital roles in the regulation of gene expression, DNA damage repair, chromatin dynamics, etc.
Host:
Rabbit
Immunogen:
Acetylated human histone H3 (Lys64) peptide
Isotyp:
IgG, kappa
Aufreinigung:
Protein A Purified
Reaktivitäten:
Human, Mouse, Rat
Versandbedingungen:
Blue Ice
Lagerbedingungen:
-20[o]C Avoid freeze/thaw cycles.
Hersteller:
Elabscience
Typ:
Antibody: Recombinant Antibodies
Western Blot with Histone H3 (Acetyl Lys64) Monoclonal Antibody at dilution of 1:1000. (-): MCF-7, (+): MCF-7 + sodium butyrate (50mM, 24hr) + trichostatin A (500ng/ml, 4 hr)
Immunohistochemistry of paraffin-embedded Human cerebrum using Histone H3 (Acetyl Lys64) Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human placenta using Histone H3 (Acetyl Lys64) Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human spleen using Histone H3 (Acetyl Lys64) Monoclonal Antibody at dilution of 1:200.
Chromatin immunoprecipitation analysis of MCF-7+Sodium butyrate (50 mM, 24 hr)+trichostatin A (500 ng/ml, 4 hr) immunoprecipitated DNA by real-time PCR using primers specific for the human GAPDH-CDS, RPL30, LDHA-CDS, FOXO3a-P, FOXO3a-D, RAB20 and TuBBP10. The data are presented as enrichment of each sample relative to the total amount of input chromatin at each amplicon.