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Antikörper

Recombinant MSR1/CD204 Monoclonal Antibody

Produktgrößen
20 ul
£189,00
AN300480P-20UL
100 ul
£402,00
AN300480P-100UL
Über dieses Produkt
SKU:
AN300480P
Zusätzliche Namen:
MSR,Scvr,Msr1
Anwendung:
Flow Cytometry, IHC-Paraffin, Immunocytochemistry, Immunofluorescence
Buffer:
PBS
translate.label.attr.clone:
B410
Klonalität:
Monoclonal
Konzentration:
1 mg/ml
Weitere Details:
Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1/SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low-density lipoproteins (LDL). MSR1/SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.
Host:
Rabbit
Immunogen:
Recombinant Mouse MSR1/CD204 protein
Isotyp:
IgG
Aufreinigung:
Protein A Purified
Reaktivitäten:
Mouse
Versandbedingungen:
Blue Ice
Lagerbedingungen:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:
Elabscience
Typ:
Antibody: Monoclonal Antibody
Immunofluorescence analysis of Mouse MSR1 in RAW264.7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Mouse MSR1 monoclonal antibody (1:100) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to plasma membrane.
Immunohistochemistry of paraffin-embedded mouse liver using MSR1/CD204 Monoclonal Antibody at dilution of 1:100.
Flow cytometric analysis of Mouse MSR1(CD204) expression on Raw264.7 cells. Cells were stained with purified anti-Mouse MSR1(CD204), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.