Recombinant VE-Cadherin/CD144/CDH5 Monoclonal Antibody
Produktgrößen
20 ul
£189,00
AN300186P-20UL
100 ul
£402,00
AN300186P-100UL
Über dieses Produkt
- SKU:
- AN300186P
- Zusätzliche Namen:
- CDH,Cadherin 5 Type,cadherin,CDH5,7B4,CD144,cadherin-5,Cadherin 5 Type 2,VE-Cadherin,Cadherin-5,7B 4,7B4 antigen,CADH5,Cadherin 5,Cadherin5,CD 144,CD144 antigen,CDH 5,CDH5 protein,Endothelial specific cadherin,FLJ17376,OTTHUMP00000174777,type 2,type 2 (vascular endothelium),vascular endothelial,Vascular endothelial cadherin,Vascular epithelium cadherin,VE Cad,VE cadherin (vascular epithelium),VEC
- Anwendung:
- Flow Cytometry, Immunocytochemistry, Immunofluorescence
- Buffer:
- PBS
- translate.label.attr.clone:
- B104
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human VE-Cadherin / CD144 / CDH5 Protein
- Isotyp:
- IgG
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:cdh5_monoclonal_antibody-an300186p