Recombinant BLyS/TNFSF13B/BAFF Monoclonal Antibody
Produktgrößen
100 ul
£402,00
AN300173P-100UL
Über dieses Produkt
- SKU:
- AN300173P
- Zusätzliche Namen:
- UNQ,PRO,ZTNF,TNF- and APOL-related leukocyte expressed ligand,TNFSF,TNFSF13B,BAFF,BLYS,CD257,DTL,TALL-1,TALL1,THANK,TNFSF20,TNLG7A,ZTNF4,Tumor necrosis factor ligand superfamily member 13B,B lymphocyte stimulator,B-cell-activating factor,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1,UNQ401,PRO738,BAFF,TNFSF13b,TALL-1,ApoL related ligand TALL 1,B cell Activating Factor,CD 257,CD257 antigen,Delta BAFF,Dendritic cell derived TNF like molecule,DTL precursor,soluble form,TALL 1,TN13B,TNF and APOL related leukocyte expressed ligand 1,TNF homolog that activates apoptosis,TNF homolog that activates apoptosis NKFB and JNK.,Tumor necrosis factor (ligand) superfamily member 13b,Tumor necrosis factor ligand 7A,Tumor necrosis factor ligand superfamily member 20,Tumor necrosis factor like protein ZTNF4,Tumor necrosis factor superfamily member 13B
- Anwendung:
- Flow Cytometry, Immunoprecipitation, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- A1287
- Klonalität:
- Recombinant Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- BAFF, a member of the TNF superfamily of proteins, is a homotrimeric transmembrane protein, which is cleaved to produce a soluble cytokine. BAFF may also further oligomerize into 60-mer structures. BAFF is expressed by monocytes, neutrophils, macrophages, dendritic cells, activated T cells, and epithelial cells. BAFF plays a key role in B cell development, survival, and activation. BAFF binds to three distinct receptors, BAFF-R, TACI, and BCMA. These receptors are differentially expressed during B cell development and among B cell subsets. While BAFF-R and BCMA bind to the homotrimeric form of BAFF, TACI only binds to membrane bound or higher order BAFF structures. The BAFF/ BAFF-R interaction activates both canonical and non-canonical NF-K KappaB pathways, PI3K/Akt, and mTOR. Activation of the noncanonical NF-K KappaB pathway via BAFF-R is negatively regulated by TRAF3. Research studies have shown that elevated levels of BAFF may exacerbate many autoimmune disorders, making it a potential therapeutic target.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human BLyS / TNFSF13B / BAFF protein
- Isotyp:
- IgG
- Aufreinigung:
- Protein A Purified
- Reaktivitäten:
- Human
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Typ:
- Antibody: Recombinant Antibodies
- Datenblatt des Herstellers:baff_monoclonal_antibody-an300173p