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Antikörper

Recombinant HPGD/15-PGDH Monoclonal Antibody

Produktgrößen
100 ul
£402,00
AN300028P-100UL
Über dieses Produkt
SKU:
AN300028P
Zusätzliche Namen:
PGDH,SDR36C,PGDH1,SDR36C1,HPGD,15 hydroxyprostaglandin dehydrogenase [NAD+],15 PGDH,15-Hydroxyprostaglandin Dehydrogenase [NAD(+)],15-hydroxyprostaglandin dehydrogenase [NAD+],15PGDH,15-PGDH,Hydroxyprostaglandin dehydrogenase 15 (NAD),NAD+ dependent 15 hydroxyprostaglandin dehydrogenase,OTTHUMP00000218960,OTTHUMP00000219016,OTTHUMP00000219018,PHOAR1,Prostaglandin dehydrogenase 1,Short chain dehydrogenase/reductase family 36C member 1
Anwendung:
Flow Cytometry, Immunocytochemistry, Immunofluorescence
Buffer:
PBS
translate.label.attr.clone:
A1138
Klonalität:
Recombinant Monoclonal
Konzentration:
1 mg/ml
Weitere Details:
15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing.
Host:
Rabbit
Immunogen:
Recombinant Human HPGD / 15-PGDH protein
Isotyp:
IgG
Aufreinigung:
Protein A Purified
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:
Elabscience
Typ:
Antibody: Recombinant Antibodies
Flow cytometric analysis of Human HPGD expression on Jurkat cells. The cells were stained with purified anti-Human HPGD, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Immunofluorescence staining of Human HPGD in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Rabbit anti-Human HPGD Monoclonal Antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI for nuclear staining (blue). Positive staining was localized to cytoplasm.