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Antikörper

Doublecortin/DCX Monoclonal Antibody

Produktgrößen
100 ul
£346,00
AN200080P-100UL
Über dieses Produkt
SKU:
AN200080P
Zusätzliche Namen:
DBCN;DC;LISX;SCLH;XLIS;DCX;Dbct;Doublecortex;doublecortin;Doublin;FLJ51296;Lis X;Lissencephalin X;Lissencephalin-X;Lissencephaly X linked;Lissencephaly X linked doublecortin;Lis-X;Neuronal migration protein doublecortin;OTTHUMP00000023859;OTTHUMP00000023860;OTTHUMP00000216315;OTTHUMP00000216316
Anwendung:
Immunocytochemistry, Immunofluorescence
Buffer:
0.2 um filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0
translate.label.attr.clone:
A928
Klonalität:
Monoclonal
Konzentration:
1 mg/ml
Weitere Details:
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Host:
Mouse
Immunogen:
Recombinant Human Doublecortin/DCX Protein
Isotyp:
IgG2a
Aufreinigung:
Protein A Purified
Reaktivitäten:
Human
Versandbedingungen:
Blue Ice
Lagerbedingungen:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:
Elabscience
Typ:
Antibody: Monoclonal Antibody
Immunofluorescence analysis of Human DCX in HepG2 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with Mouse anti-Human DCX Monoclonal Antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI for nuclear staining (blue). Positive staining was localized to cytoplasm.